Set as Reply is greyed out

In Exchange, whilst trying to set up a different primary SMTP address, Set as Reply is greyed out:

exchange-set-as-reply-greyed-out

The reason is that the e-mail address policy applied to this mailbox is preventing you from setting another address as the primary address. In order to select a different e-mail address as the primary address, just uncheck Automatically update e-mail addresses based on e-mail address policy at the bottom of the E-Mail Addresses’ tab:

exchange-automatically-update-e-mail-addresses-based-on-e-mail-address-policy

Now Set as Reply is no longer greyed out! 🙂

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